Cyberduck is a nice Mac FTP/SFTP GUI client that I’ve used in the past for moving files around between my desktop and some web servers. Turns out they’ve added support for moving your files directly to Amazon S3 and Mosso (RackSpace) Cloud Files. This means that you can use the same tool that you may previously have used for publishing content to your own web server to instead publish content directly to a self-service CDN. Amazon uses it’s Cloud Front service to distribute files, and Mosso is supposed to be integrated with LimeLight networks for distributing content from the Cloud Files system.
Just wish I had these services available to me three years ago. They would have saved me some serious cash on bandwidth commits for CDNs for those silly little projects I was working on.